High-Throughput investigation of GPCR function
- Johns Hopkins University
- Chemistry-Biology Interface Program
- Dates: Aug 2013 – Dec 2016
The goal of this project is to use innovative and advanced
molecular biology tools for high-throughput expression of
transmembrane proteins (such as GPCRs and RTKs) on the viral
envelope of herpes virions and to use these viral stocks for the
development of a unique microarray expressing a few thousand
proteins of both known and unknown function, which can be probed
for function and activity.
High resolution 3D structural investigation
- Advisor: Dr. Sriram Subramaniam
- National Cancer Institute
- Laboratory of Cell Biology
- Dates: Sep 2012 – Sep 2013
During this fellowship, I gained experience with cryoelectron
tomography as a method for macromolecular structural
determination, including computational methods for 3D data
analysis. I was also an operator of the lab's experimental focused
ion-beam scanning electron microscope (FIB-SEM), which can take 3D
images of cells at sub-5 nm resolutions.
Cell signaling in pancreatic islet cells
- UT Southwestern Medical Center
- Graduate School of Biomedical Science
- Dates: April – August 2011
My aim was to elucidate the nature of interaction between AMP
Kinase (AMPK) and ERK MAP Kinases in mouse pancreatic α and β
islet cells and the effect this interaction has on the secretion
of glucagon and insulin, hormones that regulate energy usage
throughout the body.
Exploration of semiconductor nanoclusters
- Advisor: Dr. Peter Kroll
- University of Texas at Arlington
- Department of Chemistry and Biochemistry
- Dates: April 2009 – Aug 2012
Gallium nitride is a semiconductor used in optoelectronic
devices such as blue lasers. Like many substances, GaN exhibits
interesting optical and electronic properties in the
nanoscale. The goal of my project was to computationally
characterize GaN nanoclusters embedded in silica.
Indo-US Joint Center for Human Health Care
- Advisor: Bikramjit Basu
- Indian Institute of Technology, Kanpur (India)
- Dates: 2009 – 2010
The last few decades have witnessed significant research
efforts in scientific community to integrate the concepts of
materials science and biological sciences in order to develop
biomaterials for orthopedic applications. We set out to
characterize a novel HDPE-alumina-HAp composite system. This work
was published in a peer-reviewed
journal.